Most of the games for the Atari 2600 were some degree of odd, and Plaque Attack has got to be one of the oddest.
Plaque Attack takes place inside a gigantic mouth with eight gigantic teeth. Your job, as an impossibly-tiny tube of toothpaste is to stop the squadrons of flying foodstuffs from decaying and eventually destroying your beautiful teeth.
Just like real life food, the flying foodstuffs in this game can be brought down and completely obliterated by shots from your tube of toothpaste. If you miss shooting the food, it gloms to a tooth, and will eventually destroy it.
I only played this game one time, and at the time thought it was pretty lame. It was way too easy, and the concept was just silly (and not ’silly in a good way’). However, I now know that it’s a semi-rare game that is sought after by collectors. I can’t fathom why they would want it. I thought it was terrible when I was eight years old, and odds are fairly slim that it’s gotten better with age.